Kratom relieves the depression will not be a surprise to anyone who is aware of their effects. But any statement needs scientific support.
A tangle of alkaloids…
Characterize each of them, their effects and synergy is difficult. Mitragynine (mitragynine) is the most abundant of Kratom (one 2/3 in varieties Thailand’s) alkaloid and elected by the Faculty of Medicine and Health Sciences of the University Putra Malaysia, for investigation. Learn more on kratom legend.
Research in animal models
It is a pity that there are no serious studies on the effects of Kratom intake in humans. In this study conducted in rats they were evaluated 2 models that predict antidepressant activity of mitragynine and its effect on the neuroendocrine system (HPA axis) are proof of the forced swimming test and the tail suspension. These models are currently used to evaluate the efficacy of a drug antidepressant potential.
Mitragynine, the most abundant Kratom indole alkaloid, turns out to be antidepressant. Not only passes the test, but significantly reduces the release of corticosterone, a hormone related to stress in rodents and other non-human mammals.
The doses used are high, but it is usual in these studies: rodents metabolize drugs faster than humans. They were used 10 mg / kg and 30 mg / kg.
A 70 kg adult consuming 10 grams tea Kratom Thai ingests ~ 33 mg of mitragynine (excluding other alkaloids), equivalent to 0.47 mg / kg.
Still, many users of Kratom believe that this dose may be sufficient to achieve an antidepressant effect.
And do not forget…
In Kratom alkaloids are other playing a very important role and synergy between them is discovered. If you want to give an opportunity to Kratom as an antidepressant, remember that the Thai varieties are more mitragynine that the Malays (66% vs 12%).
Although as has only been studied in this aspect mitragynine, we cannot say that the variety Malaya have antidepressant properties under the Thai, for the first contains many barely known alkaloids.